Endocrine Abstracts

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Enzymatic 5′- and 5-deiodination represent key pathways for local and systemic and local activation and inactivation of iodothyronines and iodothyronamines. Expression of the three respective deiodinases (DIO) is regulated by thyroid parameters, local and systemic inflammatory status as well as by selenium supply. In addition, the DIO isoenzymes are intended but also unanticipated target proteins of pharmacological, nutritive and environmental substances that might inter...

Introduction: Glucosinolates (GLS) are secondary plant metabolites found in members of families within the order Brassicales (e.g. broccoli, pak choi, cauliflower, kale, mustard or rapeseed), but they are also present in plants of Moringaceae (moringa) and Caricaceae (papaya). Some GLS-derived breakdown products, i.e. sulforaphane, were extensively studied for their beneficial effects on colon-cancer incidence. This preventive nutritional approach might require the prophylacti...